Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Post-operative creatinine clearance
Study Overview
Brief Summary
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •end-stage renal disease, for living-donor kidney transplantation
Exclusion Criteria
- •severe cardiac or hepatic dysfunction
- •coagulopathy
Arms & Interventions
C group
Adequate hydration
Intervention: Adequate hydration (Procedure)
M group
Mannitol infusion
Intervention: Mannitol infusion (Procedure)
D group
Dopamine infusion
Intervention: Dopamine infusion (Procedure)
Outcomes
Primary Outcomes
Post-operative creatinine clearance
Time Frame: 7 days
Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min
Secondary Outcomes
No secondary outcomes reported
Investigators
Nazmy Edward Seif
Clinical Professor
Cairo University