China Registry of Non-disabling Ischemic Cerebrovascular Events
- Conditions
- Transient Ischemic AttackMinor Stroke
- Registration Number
- NCT03079674
- Lead Sponsor
- The First Affiliated Hospital of Zhengzhou University
- Brief Summary
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. In order to achieve accurate risk stratification and effective treatments, developing new diagnostic, therapeutic, and prognostic strategies is indispensable. Chinese registry of NICE is a national multi-center prospective study aimed to explore the epidemiology, new biomarkers, risk factors and prognostic models.
- Detailed Description
The pathophysiology of transient ischemic attack (TIA) and minor stroke is a continuous progression. TIA and minor stroke exhibit the common substantial risk factors for early stroke recurrence and epidemiological characteristic. Since TIA and minor stroke may leave impermanent or mild neurological deficit, they are termed as non-disabling ischemic cerebrovascular disease (NICE).
The results of the China Chronic Disease and Risk Factor Surveillance (CCDRFS) 2010 showed that the age-standardized prevalence of TIA is 2.27%. Estimated 23.9 million people may have experienced a TIA in China. The TIA knowing-rate is approximately 3.08% in Chinese adults, only 5.02% received treatment and 4.07% received guideline recommended therapy. The Second China National Stroke Registry (CNSR-II) indicated that minor stroke accounted for 42.23% of all the hospitalized patients of ischemic stroke, which is much higher than that showed in CNSR-I (2007-2008). Thus, it is imperative to develop new strategies to improve the diagnosis, risk prediction and appropriate management of NICE.
NICE is an attractive researching area globally. According to the large quantities of NICE patients in China and the low standardized therapeutic rate, the awareness of NICE is largely insufficient. The purpose of the present study is to establish a multi-center national prospective database of NICE, including clinical information and biological samples library and, to further explore the epidemiology, new biomarkers, risk factors, and prognostic models.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10000
- ≥18 years old
- elapsed time from last episode to registry <48 hours
- patients who refused to participate in the research, and patients who failed to complete the follow-up protocol.
- patients with malignant tumors, or patients with severe liver or kidney disease, whose life expectancy is less than 1 year.
- patients who received endovascular or thrombolytic therapy.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death 12 months Death from any cause
Stroke recurrence 12 months Ischemic stroke
- Secondary Outcome Measures
Name Time Method Hemorrhagic stroke 12 months Cerebral hemorrhage and subaraclmoid hemorrhage
Cardiovascular disease 12 months Coronary heart disease and Angina pectoris
Functional outcome 12 months Modified Rankin Scale ≥3
Trial Locations
- Locations (44)
Chongqing Three Gorges Central Hospital
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Jiangmen Central Hospital
🇨🇳Jiangmen, Guangdong, China
Yuebei People's Hospital
🇨🇳Shaoguan, Guangdong, China
Shijiazhuang the Third Hospital
🇨🇳Shijiazhuang, Hebei, China
Xingtai Third Hospital
🇨🇳Xingtai, Hebei, China
Anyang People's Hospital
🇨🇳Anyang, Henan, China
The People's Hospital of Hebi
🇨🇳Hebi, Henan, China
The Second People 's Hospital of Jiaozuo
🇨🇳Jiaozuo, Henan, China
The Huaihe Hospital of Henan University
🇨🇳Kaifeng, Henan, China
Scroll for more (34 remaining)Chongqing Three Gorges Central Hospital🇨🇳Chongqing, Chongqing, ChinaShengli Chen, MDContact138962269602271487396@qq.com