A randomized, double blinded, placebo controlled clinical trial to evaluate the efficacy of intranasal Dexmedetomidine as premedicant to attenuate haemodynamic response of laryngoscopy and intubation in elective lumber spine surgery.

Bangur Institute of Neurosciences Kolkata0 个研究点目标入组 70 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•Patients with ASA physical status I, patients having Mallampati I and II, patients with body mass index (BMI) < 30 kg/m2.

•Patients refusal to participate in the study.Known allergy or hypersensitive reaction to dexmedetomidine or diazepam. Patients suffering from significant cardiac disease e.g IHD, cardiomyopathy, valvular disorder, hypertension, arrhythmia, etc. Patients suffering from significant respiratory disease e.g COPD, bronchial asthma, interstitial lung diseases, pneumonia etc. Patients having metabolic, endocrinal, musculoskeletal, neurologic disorder or having major congenital anomalies. History of drug abuse and/or psychiatric disorder. Pregnant women; no reliable contraceptive measures in postmenopausal women. Patients taking antihypertensive drugs such as methyldopa, clonidine and other Î±2 receptor agonists. Patients having morbid obesity, obstructive sleep apnoea, suspected difficult airway. Patients having liver and kidney dysfunction. Patients having long-term use of sedatives and analgesics. Patients having Mallampati grades III and IV.

发起方

Bangur Institute of Neurosciences Kolkata