Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Not Applicable

Completed

• Conditions: Candida Infection; Peritonitis Infectious
• Interventions: Other: To evaluate the initial levels and kinetics of serum β-D-glucan

• Registration Number: NCT03140748
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-04-14
• Study First Submitted QC: 2017-05-02
• Study First Posted: 2017-05-04
• Study Start: 2018-05-01
• Primary Completion: 2021-08-22
• Study Completion: 2023-06-01
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-05
• Last Update Posted: 2023-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Major Patient (age ≥ 18 years)
• Community or associated peritonitis, operated and hospitalized in resuscitation
• Affiliation to a social security scheme

Exclusion Criteria

• Allergy known to echinocandins
• Dying Patient
• Limitation of care
• Predictable duration of follow-up ≤ 10 days
• Transfusion within 3 months
• Patient minor, patient under guardianship or curatorship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with fungal peritonitis	To evaluate the initial levels and kinetics of serum β-D-glucan	-
Patients with peritonitis without yeast	To evaluate the initial levels and kinetics of serum β-D-glucan	-

Primary Outcome Measures

Name	Time	Method
Blood determination of serum β-D-glucan kinetics in patients with peritonitis	28 days	Blood determination of serum β-D-glucan kinetics in patients with peritonitis

Trial Locations

Locations (1)

CHU Amiens Picardie; 🇫🇷 Amiens, Picardie, France