Optimization Principles in Hemiparetic Gait

Not Applicable

Recruiting

• Conditions: Stroke
• Interventions: Behavioral: Manipulation of spatiotemporal coordination during walking

• Registration Number: NCT03916562
• Lead Sponsor: University of Southern California

Brief Summary

This project seeks to identify the how walking impairments in stroke survivors contribute to mobility deficits through the use of behavioral observations and computational models. The chosen approach integrates biomechanical analyses, physiological assessments and machine learning algorithms to explain how asymmetries during walking influence balance and the effort required to walk. Ultimately, the results of this work may lead to more personalized rehabilitation strategies to improve walking capacity and efficiency, and ultimately reduce fall risk in stroke survivors.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-13
• Study First Submitted: 2019-03-31
• Study First Submitted QC: 2019-04-11
• Study First Posted: 2019-04-16
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-19
• Last Update Posted: 2023-05-23
• Primary Completion: 2023-11-30
• Study Completion: 2023-11-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy Participants	Manipulation of spatiotemporal coordination during walking	The investigators will determine how asymmetric walking constraints influence spatiotemporal coordination, energetic cost, and dynamic balance in healthy individuals. The investigators will manipulate spatiotemporal coordination using a special treadmill. Energetic cost will be quantified using expired gas analysis and inverse dynamic approaches. Stability will be evaluated by characterizing participants' ability to recover from unexpected perturbations.
Post-stroke Participants	Manipulation of spatiotemporal coordination during walking	The investigators will determine how different patterns of coordination during walking influence energetic cost and dynamic balance in people post-stroke. The investigators will manipulate coordination using a special treadmill. Energetic cost will be quantified using expired gas analysis and inverse dynamic approaches. Stability will be evaluated by characterizing participants' ability to recover from unexpected perturbations.

Primary Outcome Measures

Name	Time	Method
Correlation between angular momentum and step length asymmetry during walking	During study day two	Participants will complete five trials at different levels of step length asymmetry. During these trials, motion capture will be used to measure the kinematics of the body when participants respond to accelerations of the treadmill. This outcome measure will use data from all trials to determine the relationship between angular momentum and step length asymmetry.
Oxygen consumption (VO2)	At the beginning of study day one	The investigators will use a metabolic cart to measure the rate of oxygen consumption (VO2) while participants walk at a fixed speed on a treadmill.
Correlation between oxygen consumption (VO2) and step length asymmetry	During study day one	The investigators will use a metabolic cart to measure the rate of oxygen consumption (VO2) while participants walk at a fixed speed on a treadmill. VO2 will be measured in five trials where participants walk with different levels of step length asymmetry. This outcome will capture the relationship between measures of VO2 and step length asymmetry.
Angular momentum during walking	At the beginning of study day two	Motion capture will be used to measure the kinematics of the body when participants respond to accelerations of the treadmill

Trial Locations

Locations (1)

University of Southern California; 🇺🇸 Los Angeles, California, United States