Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht.

Recruiting

Conditions: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Registration Number: NL-OMON23472

Lead Sponsor: one. Investigator initiated study.

Brief Summary: Tas J, van Gassel R, Heines S, et al. Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort; MaastrICCht. medRxiv doi: 10.1101/2020.04.27.20080309

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 250

Inclusion Criteria

Intensive care admission with signs and symptoms of a viral infection
- Intubated and mechanically ventilated
- PCR positive for SARS-CoV-2 and/or a chest CT scan scored positive based on a CORADS-score of 4-5 by a radiologist

Exclusion Criteria

None.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical data, laboratory results, EIT measurements and vital parameters will be collected within the MaastrICCht cohort. As multiple hypotheses can be investigated within the observational cohort, no predefined primary outcome for the whole cohort will be defined. <br><br>Rather, investigators have to submit a data request including a predefined analysis plan according to reporting guidelines appropriate for the type of study (i.e., STROBE for observational studies, STARD for diagnostic studies, TRIPOD for prognostic studies; see the Enhancing the QUAlity and Transparency Of health Research network at www.equator-network.org for detailed information). All external researchers submitting a data request will be required to produce a statistical analysis plan that will be reviewed by the cohort steering committee.

Secondary Outcome Measures