Effect of age on the median effective dose and 95% effective dose of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation: a double-blind, up-and-down sequential method trial
Phase 4
Completed
- Conditions
- Patients undergoing general anesthesia with endotracheal intubation.Fentanyl, Hemodynamic Response, Tracheal Intubation
- Registration Number
- TCTR20210527001
- Lead Sponsor
- eurological Institute of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 86
Inclusion Criteria
1. Age 20 - 80 years
2. Undergoing general anesthesia with ETT
3. Elective surgery
4. ASA physical status I or II
5. No history of fentanyl allergy
Exclusion Criteria
1. In OR, at the time of induction ( BP greater than or equal to 180/110 mmHg)
2. Expected difficult airway
3. BMI greater than or equal to 30 kg/m2
4. Fentanyl was given within 4 hours of admission to the study
5. Ischemic heart disease, arrhythmia
6. Increased ICP
7. Creatinine clearance less than 30 ml/min
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Median Effective Dose (ED 50) and 95% Effective Dose (ED 95) of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation at 1, 3, 5, 10 minutes after end of the intervention The Median Effective Dose (ED 50) and 95% Effective Dose (ED 95)
- Secondary Outcome Measures
Name Time Method The incidence of adverse events associated with the use of fentanyl at 1, 3, 5, 10 minutes after end of the intervention Patient reported outcome using a question. Clinical signs and hemodynamic changes were observed.