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临床试验/NCT03555513
NCT03555513已完成不适用

The Frequency and Risk Factors of Delayed Graft Function in Living Donor Kidney Transplantation and Its Clinical Impact in Part of Middle East

nooshin dalili0 个研究点目标入组 500 人开始时间: 2016年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
500
主要终点
incidence of delayed graft function

研究概览

简要总结

Delayed graft function (DGF) is an important phenomenon after kidney transplantation with direct and indirect implication on graft survival. Although its incidence and risk factors have been studied after cadaveric kidney transplantation cases, only few data is available regarding transplants from living donors. The present study was performed to investigate the frequency and risk factors of DGF among living-unrelated kidney transplant recipients among three transplant centers in part of Middle East.

详细描述

In this multi-center retrospective study, data from 480 transplanted patients had been collected from existing local hospital registries in three countries (Iran, Kingdom of Saudi Arabia (KSA), and Kuwait) with 3 years post transplantation follow-up. Data for this study was collected based on routine clinical practice of medical practitioners across the participating countries. A case report data collecting form was designed for gathering the data including the recipient and donor's characteristics prior to transplantation, and after transplantation up to three years post transplantation. Using binary logistic regression analysis, the potential risk factors for occurrence of DGF in living donor transplantations were tested. Graft and patient survival at 1, 2 and 3 years depending on follow-up time was evaluated.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Living donor kidney recipients with complete prior transplantation data and 3 years post transplantation follow up, including those who died during the observation period

排除标准

  • kidney recipients younger than 18 years

结局指标

主要结局

incidence of delayed graft function

时间窗: 3 years

次要结局

  • risk factors of DGF(three years)

研究者

申办方类型
Other
责任方
Sponsor Investigator
主要研究者

nooshin dalili

Assistant Professor of SBMU

Shahid Beheshti University of Medical Sciences

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