COVID-19 Infection and Epithelial Cell Markers
试验速览
- 阶段
- 不适用
- 入组人数
- 235
- 试验地点
- 1
- 主要终点
- TSLP expression in nasal epithelium
研究概览
简要总结
To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.
详细描述
The study aim is to determine the relationship between COVID-19 infection and epithelial cell expression of TSLP. Two cohorts will be used. Cohort One will include 100 hospitalized patients with Covid-19, and 100 hospitalized patients without Covid-19. Cohort 2 will include mild/moderate asthmatics and healthy controls with bio-banked biopsy material used from donors who have previously consented for samples to be used for future research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years and above;
- •Able to give informed consent;
- •Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g. RT-PCR) and with a positive result and clinical features in keeping with COVID-19 illness. The control group will be patients with a negative RT-PCR COVID-19 test and without any clinical features to suggest COVID-19 illness. In addition, the control group should have NO known or current features of respiratory infection, COPD, asthma, interstitial lung disease, other respiratory inflammatory conditions or lung cancer.
- •Able to provide a breath sample (as based on clinical judgement).
排除标准
- 未提供
结局指标
主要结局
TSLP expression in nasal epithelium
时间窗: Through study completion, an average of 1 year
Compare the level of TSLP expression in nasal epithelium in patients with and without COVID-19 infection
次要结局
- TSLP expression in endobronchial biopsies(Baseline)
- IL-33 expression in endobronchial biopsies(Baseline)
- ACE-2 receptor expression in endobronchial biopsies(Baseline)
研究者
Gail Gauvreau
Professor Department of MEdicine
McMaster University