Application of Adenosine 5'-Triphosphate (ATP) Infusions in Palliative Home Care
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 5
- 主要终点
- Survival Physical restriction Fatigue Quality of life
研究概览
简要总结
Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status, quality of life, and survival. Based on these promising results, the present study was designed 1. To evaluate whether the beneficial effects of ATP administration observed in patients with advanced lung cancer would also be present in pre-terminal cancer patients of different tumour types, and 2. To test the feasibility of application of ATP infusions in a home care setting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cytologically or histologically confirmed cancer
- •medical treatment options restricted to supportive care
- •a life expectancy < 6 months
- •World Health Organization (WHO) performance status 1 or 2
- •suffering from at least one of the following complaints: fatigue, weight loss > 5% over the last 6 months, or anorexia
排除标准
- •symptomatic angina pectoris
- •symptomatic heart failure
- •any form of atrioventricular (AV) block (assessed by electrocardiogram)
- •life expectancy < 4 weeks
- •concurrent palliative chemotherapy
- •cognitive dysfunction, and other diseases hampering adequate follow up
研究组 & 干预措施
I
干预措施: Adenosine 5'-triphosphate (Drug)
结局指标
主要结局
Survival Physical restriction Fatigue Quality of life
时间窗: 0-8 weeks
次要结局
- Appetite Nutritional intake Body height Body weight Triceps skin fold thickness Mid-upper arm circumference Strength of elbow flexor and knee extensor muscles Handgrip strength Process evaluation(0-8 weeks)