Perfenidone in Endomyocardial Fibrosis patients

Endomyocardial Fibroisis is a disease with no curative treatment or drug to limit fibrosis progression . Perfenidone is an anti fibrotic drug which is approved for treatment of idiopathic pulmonary fibrosis which is also characterised by diffuse severe fibrosis of lungs. Perfenidone has shown good results in randomised controlled trails for this condition . We plan to test perfenidone for end-myocardial fibrosis patients and use cardiac MRI to evaluate its effect on the progression of disease over one year.