JPRN-jRCTs041180110已完成3 期
Carboplatin plus nab-Paclitaxel versus docetaxel for elderly squamous non-small cell lung cancer - CAPITAL study
Gemma Akihiko0 个研究点目标入组 196 人开始时间: 2019年3月19日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 196
研究概览
简要总结
The combination of carboplatin plus nab-paclitaxel in advanced squamous cell lung cancer in elderly patients significantly prolongs overall survival and is a more useful treatment than docetaxel.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 70age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) Histologically or cytologically confirmed advanced squamous non-small-cell lung cancer
- •2) Clinical stage IIIB (not amenable to curative radiation), IV or recurrent disease
- •3) Regardless of the presence of measurable lesions
- •4) 70 years of age or older
- •5) Performance status of 0 or 1
- •6) Adequate organ function
- •7) life expectancy 12 weeks or more at day1
- •8) Written informed consent
排除标准
- •1) symptomatic central nervous system metastases
- •2) A past hypersensitive for polysorbate or albumin
- •3) peripheral neuropathy CTCAE Grade 2 or more
- •4) uncontrolled pericardial or pleural effusion or ascites
- •5) prior palliative radiotherapy for metastatic lesion within 14 days before registration
- •6) Synchronous or metachronous active double malignancies
- •7) Infectious disease requiring systemic treatment or severe complications
- •8) do not consent to contraception
- •9) Positive for HBs antigen
- •10) positive for HBs antibody or HBc antibody, and positive for HBV-DNA
- •11) patients who have been judged by the investigator to be inappropriate in this clinical trial for other reasons
研究者
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