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临床试验/CTRI/2025/08/093168
CTRI/2025/08/093168尚未招募4 期

Comparative evaluation of nebulized dexamethasone with nebulized dexmedetomidine for reduction in incidence of post-operative sore throat in patients undergoing laparoscopic cholecystectomy under general anesthesia with endotracheal intubation

ABHISHEK CHATTERJEE0 个研究点目标入组 132 人开始时间: 2025年9月2日最近更新:

试验速览

阶段
4 期
状态
尚未招募
发起方
入组人数
132
主要终点
incidence and severity of postoperative sore throat

研究概览

简要总结

132 Patients fulfilling the inclusion criteria will be randomly allocated into three equal groups. Group S will receive 8mg nebulized dexamethasone. Group D will receive 50mcg nebulized dexmedetomidine and Group P will receive 5ml nebulized normal saline. The incidence and severity of postoperative sore throat along with incidence of hoarseness of voice and cough will be observed at four different time points after extubation

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • ASA 1 ASA 2 Scheduled for elective laparoscopic cholecystectomy surgery.

排除标准

  • ASA 3 ASA 4 history of allergy to study drugs anticipated difficult airway uncontrolled comorbid conditions.

结局指标

主要结局

incidence and severity of postoperative sore throat

时间窗: 2 hours, 6 hours, 12 hours, 24 hours after extubation

次要结局

  • incidence of hoarseness of voice, cough(2 hours, 6 hours, 12 hours, 24 hours after extubation)

研究者

发起方
ABHISHEK CHATTERJEE
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

ABHISHEK CHATTERJEE

TATA MAIN HOSPITAL

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