Combining Behavioral Treatment With Agonist Maintenance - 1

Phase 3

Completed

• Conditions: Substance-Related Disorders; Cocaine-Related Disorders; Opioid-Related Disorders
• Interventions: Drug: methadone; Drug: Buprenorphine

• Registration Number: NCT00000311
• Lead Sponsor: Yale University

Brief Summary

The purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist maintenance treatment and at 3 and 6 month follow-up after completion of study protocol, and to compare the efficacy of maintenance on buprenorphine to methadone when maintenance is combined with CRA only or CRA plus CM.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-02
• Primary Completion: 1999-02
• Study Completion: 1999-02
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-12
• Last Update Posted: 2018-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 168

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
1	methadone	Methadone + CM (contingency management)
2	methadone	methadone + VC (voucher control)
3	Buprenorphine	Buprenorphine + CM
4	Buprenorphine	Buprenorphine + VC

Primary Outcome Measures

Name	Time	Method
Withdrawal symptoms
Depression	24 weeks
Opioid and cocaine use
Social and psychological functioning
AIDS risk behavior

Trial Locations

Locations (1)

APT Residential Services Division; 🇺🇸 New Haven, Connecticut, United States