Ultra sonographic changes of Optic Nerve Sheath Diameter in Severely pre-eclamptic patients treated with Magnesium Sulphate

Completed

• Conditions: Severe pre-eclampsia,

• Registration Number: CTRI/2019/08/020951
• Lead Sponsor: TEERTHANKAR MAHAVEER MEDICAL COLLEGE

Brief Summary

Preeclampsia is one of the most common serious medical disorder of human pregnancy, complicating around 3-4% of pregnancies worldwide and it remains a leading cause of maternal mortality many such deaths being attributable to the sequelae of this condition mainly neurological events, such as eclampsia and intracranial hemorrhage along with acute pulmonary oedema and hepatic rupture. Again, it is the neurological complications of this condition that result in most of the morbidities , including blindness, persistent neurological deficits secondary to stroke, and later cognitive impairment. The newborns are also susceptible to neurological,cardiovascular and metabolic diseases in later life.

Clinical signs of raised intracranial pressure (ICP) are not specific and often present late and are  difficult to interpret during pregnancy and preeclampsia. The actual incidence of raised ICP in preeclampsia and eclampsia is unknown. The gold standard method for ICP measurement isbased on invasive devices which is often not feasible in pregnancy. Many studies had suggested that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) can give a fair idea of raised ICP especially in neurocritical care such as stroke, meningitis ,CNS trauma,and epilepsy. Magnesium Sulphate (MgS04) has been used since ages in obstetrics for the prevention and treatment of seizures in pre-eclamptic and eclamptic parturients. However its effect on raised ICP is still unclear. Assuming OSND as a surrogate marker for raised ICP we evaluated effect of MgSO4 on ONSD and hence raised ICP .

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-09
• Study Completion: 2020-03-31
• Last Update Posted: 2021-07-08

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

Parturients giving written informed consent, Antenatal patient diagnosed to have severe pre-eclampsia Patient about to receive Magnesium Sulphate therapy.

Exclusion Criteria

Chronic hypertension Hyperthyroidism High myopicPresence of ocular wound Prior ocular surgery Presence of oliguria and deranged KFT.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Optic nerve sheath diameter will be measuremed transorbitally by ultrasound in severe preeclamptic patient and will be compared with optic nerve sheath diameter at different time intervals after administration of MgSO4 treatment.	just prior to start of MgSO4 therapy and at 2hr, 4hr, 6hr,12hrs and 24 hrs after start of therapy.

Secondary Outcome Measures

Name	Time	Method
Haemodynamic changes following MgSo4 theray	Neurological signs and symptoms before and following MgSO4 therapy.

Trial Locations

Locations (1)

TEERTHANKAR MAHAVEER MEDICAL COLLEGE; 🇮🇳 Moradabad, UTTAR PRADESH, India

TEERTHANKAR MAHAVEER MEDICAL COLLEGE

🇮🇳Moradabad, UTTAR PRADESH, India

Kanchan Rani

Principal investigator

07017621406

drkanchanrani@gmail.com