Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment

Not Applicable

• Conditions: K05.3; Chronic periodontitis

• Registration Number: DRKS00023158
• Lead Sponsor: niversitätsmedizin der Johannes Gutenberg-Universität Mainz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-10-25
• Study Start: 2020-09-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

diagnosis of periodontitis stage II or III and grade B
- presence of at least six sites with PPD = 5mm
- bleeding on probing
- at least 20 remaining teeth

Exclusion Criteria

- diabetes mellitus
- HIV
- heart disease
- osteoporosis
- lactose intolerance
- a positive history of periodontal or antibiotic treatment in the previous six months
- smoking
- pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome measures were differences (in mm) between the groups for changes in pocket depth after 3 and 6 months compared to baseline. Probing pocket depth was measured from the free gingival margin to the bottom of the periodontal pocket with a conventional periodontal probe (PCP-UNC 15, Hu-Friedy®, Chicago, IL, USA).

Secondary Outcome Measures

Name	Time	Method
Secondary outcome measures included clinical attachment level (mm), bleeding on probing, Gingiva-Index simplified, Plaque-Control-Record, and counts of the bacterial species. <br>Clinical attachment level and bleeding on probing were measured at six sites per tooth (mesio-buccal, buccal, disto-buccal, disto-lingual, lingual and mesio-lingual) using a conventional periodontal probe (PCP-UNC 15, Hu-Friedy®, Chicago, IL, USA).<br>Subgingival plaque samples were collected at baseline, 3 and 6 months following treatment from the deepest pocket of each quadrant. The samples were transferred to a sterile vial (pooled sample) and sent to a commercial laboratory for analysis. The analysis was performed with a commercially available DNA probe kit (IAI Pado Test, Institute of Applied Immunology, IAI, Zuchwil, Switzerland) to identify the following periopathogenic microorganisms: A. actinomycetemcomitans (Aa), T. forsythia (Tf), P. gingivalis (Pg), and T. denticola (Td).