Prospective analysis of the influence of the heart-lung machine on factor XII activity in the blood and its functional effects on coagulation capacity, bleeding and thrombosis rates
- Conditions
- A prolonged aPTT often results in postoperatively inadequate anticoagulation, which could lead to an increased rate of thromboembolic events.
- Registration Number
- DRKS00034174
- Lead Sponsor
- MU Klinikum München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Patients undergoing major cardiac surgery with intraoperative use of the heart-lung machine
- Consent of the patient or caregiver
- Age > 18 years
Exclusion Criteria
- Refusal to participate in the study by the patient or caregiver
- Age < 18 years
- Congenital or acquired coagulation disorders (both pro- and anticoagulatory)
- Blood-thinning medication in a time window of less than 12 hours before the operation, with the exception of antiplatelet agents
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Factor XII activity preoperatively versus after the end of the extracorporeal perfusion time
- Secondary Outcome Measures
Name Time Method - Correlation of factor XII activity with aPTT<br>- Correlation of factor XII activity with CT INTEM<br>- Correlation of factor VIII activity with CT INTEM or aPTT<br>- Correlation of factor V activity with CT INTEM or aPTT<br>- Correlation of factor activities with thromboembolic events or bleeding events<br>- Correlation of factor activities with transfusion volumes