Effect of Ceratonia siliqua on male infertility.

Phase 3

• Conditions: Male infertility.; Oligospermia; N46.1

• Registration Number: IRCT20171209037794N1
• Lead Sponsor: Babol University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 October 2020

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

20 - 45 years of age, who had complained of infertility for at least 12 months, and had no history of surgical or medical treatments for infertility
Unspecified oligospermia based on WHO criteria (sperm count less than 20 million per ml, type A motility less than 25%, and type B motility less than 50%; normal morphology less than 15%);
Having a BMI less than 30
Not smoking, drinking alcohol, and addiction to substance
Normal level of gonadotropins, testosterone and Prolactin
Lack of systemic diseases, such as diabetes and thyroid, cerebrovascular disease and had no history of chemotherapy

Exclusion Criteria

A history of vasectomy or obstructive azoospermia
Azospermia and chromosomal abnormalities such as kleinfelter's Syndrome
Hypogonadism or pituitary abnormalities
The use of antioxidant supplements in the last three months
Taking medications that stimulate the sexual system or disrupt the sex hormones
Having severe physical activity
Genital tract infection, recurrent or residual varicocoele and history of cryptorchidism
Infectious diseases characterized by fever and leukocytosis.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sperm count. Timepoint: Before and three months after intervention. Method of measurement: Semen analysis.;Sperm morphology. Timepoint: Before intervention and three months after intervention. Method of measurement: Semen analysis.;Sperm motility. Timepoint: Before and three months after intervention. Method of measurement: Semen analysis.

Secondary Outcome Measures

Name	Time	Method
Serum concentrations of Malondialdehyde. Timepoint: Before and three months after intervention. Method of measurement: TBARS method using Spectrophotometer.;Sex hormones. Timepoint: Before and three months after intervention. Method of measurement: Eliza.;Superoxide dismutase enzyme. Timepoint: Before and three months after intervention. Method of measurement: Calorimetric.;Zinc. Timepoint: Before and three months after intervention. Method of measurement: Atomic Absorption Spectrophotometry.;Selenium. Timepoint: Before and three months after intervention. Method of measurement: Atomic Absorption Spectrophotometry.