Comparison of nasal and bronchial house dust mite (HDM) provocation in childhood.
- Conditions
- J30.3J45.0Other allergic rhinitisPredominantly allergic asthma
- Registration Number
- DRKS00010531
- Lead Sponsor
- Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 65
Diagnosis of mite allergy (skin prick test = 3mm)
Known asthma and / or allergic rhinoconjunctivitis
Bronchial allergen challenge performed in the preceding 12 weeks
exacerbation free interval> 4 weeks before visit 1
Written informed consent of the parents and the child / adolescent
Age <5 years, age> 25 years
Exacerbation of asthma within the last 28 days
Severe symptoms of allergic rhinitis or relevant deterioration of allergic symptoms
Intake of the following drugs before testing: Decongestant nose drops one day, antihistamines three days, nasal steroids 14 days, oral cortisone four weeks, leukotriene antagonists and cromoglycic acid three days before nasal provocation challenge.
Adenoids or nasal surgery in the last three months
Serious deviation of the nasal septum
Other serious diseases (for example, cystic fibrosis, diseases with immunosuppression, malignancies)
Pregnancy, lactation
Participation in another clinical trial <30 days
Inability to understand the scope of the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Primary endpoint is the concordance of the nasal and bronchial allergen challenge for the grading negative, moderate and severe allergic reaction
- Secondary Outcome Measures
Name Time Method Correlation of peak nasal inspiratory flow and nasal symptoms to the lokal and serum IgE.<br>Comparison of the IgE repertoire (epitope spectrum) nasal vs. serum IgE.