Whey Protein and Carbohydrates in ERAS for Recovery After Thyroidectomy: A Cohort Study

Not Applicable

Completed

• Conditions: Whey Protein; Thyroid Neoplasms; Neck Dislocation; Enhanced Recovery After Surgery

• Registration Number: NCT06607965
• Lead Sponsor: Chongqing General Hospital

Brief Summary

Exploring the effects of whey protein combined with carbohydrates in an Enhanced Recovery After Surgery (ERAS) protocol on the postoperative recovery of thyroid cancer patients undergoing lateral neck dissection, aiming to provide more precise research and guidance for the perioperative accelerated recovery plan in such patients. The goal is to accelerate postoperative recovery and reduce postoperative complications for thyroid cancer patients undergoing neck dissection.

Detailed Description

Perioperative dietary management was differentiated between the two groups:

Experimental Group:

6 hours before surgery, patients orally consumed 250 ml of a full-nutrition liquid (220 ml homogenized diet, 50 g; containing 31.4 g carbohydrates, 8 g protein, and 215 kcal).

2 hours before surgery, patients orally consumed 200 ml of a clear liquid (50 g enzymatically hydrolyzed rice powder + 0.5 g low-sodium salt; containing 47.7 g carbohydrates, 6.5 g whey protein, and 193 kcal).

After surgery, once there were no symptoms such as dizziness or vomiting, patients could start consuming clear liquids (containing 47.7 g carbohydrates, 6.5 g protein, and 221 kcal) orally every 30 minutes, 4 times on the day of surgery.

Starting from the first day after surgery, patients consumed 200 ml of fat-free nutritional liquid (50 g enzymatically hydrolyzed rice powder + 7.5 g isolated whey protein + 0.5 g low-sodium salt; 223 kcal) per serving, 4 to 6 times per day as needed.

Control Group:

Patients fasted for 12 hours before surgery, and after surgery, intravenous fluids were administered. Fat-free diet began after 24 hours post-surgery.

Discharge Criteria: The discharge time was determined by the surgeon based on the patient's postoperative drainage condition and the presence or absence of complications.

Study Timeline

• Study Start: 2023-03-01
• Primary Completion: 2024-03-31
• Study Completion: 2024-05-31
• Status Verified: 2024-09
• Study First Submitted: 2024-09-13
• Study First Submitted QC: 2024-09-19
• Study First Posted: 2024-09-23
• Last Update Submitted: 2024-12-02
• Last Update Posted: 2024-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 127

Inclusion Criteria

• Aged 18 years or older;
• Differentiated thyroid cancer with lateral lymph node dissection;
• Written informed consent provided by the participant.

Exclusion Criteria

• History of chronic liver or kidney disease, ischemic heart disease, or diabetes;
• Previous neck surgery or history of iodine-131 radiation;
• Allergy to soy or whey protein;
• Intraoperative chylous leak;
• Other special types of thyroid cancer.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
hemoglobin	3 day	Record the difference in indicators before and after surgery
serum albumin	3 day	the difference in indicators before and after surgery.
weight	1week	Record the difference in indicators before and after surgery
Postoperative Complication	1 month	Record the occurrence of related surgical complications in the experimental group and the control group.

Trial Locations

Locations (1)

Chongqing General Hospital; 🇨🇳 Chongqing, Chongqing, China