Effect of MetS* on Cognitive Performance and Physical Activity (Metabolic Syndrome)
- Conditions
- Metabolic Syndrome
- Interventions
- Other: assessment of cognitive performance
- Registration Number
- NCT05702437
- Lead Sponsor
- Istanbul University - Cerrahpasa (IUC)
- Brief Summary
Metabolic syndrome (MetS) increases the risk of developing diabetes and cardiovascular disease risk factors that are linked with each other, which is a metabolic dysfunction, which contains a combination of multiple.
It is known that METS plays a role in the development of many diseases such as cardiovascular diseases, stroke, cancer, Alzheimer's. Studies have revealed that neuroinflammation, oxidative stress, abnormal lipid metabolism and impaired vascularization, which play a role in the pathogenesis of MetS, affect the structure of the brain and cognition. Atherosclerosis of the carotid artery, increased brain atrophy and white matter damage are potential explanatory mechanisms that lead to an impact on cognitive skills in patients with MetS. In addition, the existence of MetS components such as obesity, diabetes, hypertension alone also negatively affects cognitive functions, and the level of cognitive influence also increases as the number of components an individual has increases.
The literature reports that learning, executive functions, processing speed, attention/working memory and global cognitive functions are affected in individuals with MetS, but no consensus has been reached on this issue. Some studies say that MetS causes a significant decrease in cognitive functions, while some studies indicate that this difference is not significant.
The aim of our study is to proof the relationship between MetS and cognitive functions with metabolic syndrome components.
H1:There is a relationship between the MetS and cognitive functions.
- Detailed Description
Voluntary participants who have been diagnosed with MetS and agreed to voluntary health subjects will be included in the study. Signed voluntary consent will be obtained from participants. Participants will be divided into two groups. There will be individuals diagnosed with MetS in the intervention group and healthy individuals who do not have any problems in the control group.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 82
- being between the ages of 18-50
- Having been educated for at least 5 years and know how to read and write
- Having been diagnosed with MetS by meeting 3 of the NCEP-ATP III criteria (for participants in the MetS Group)
- To have a biochemistry test performed within the last 6 months (for the Healthy Group)
- Not having any MetS components (For the Healthy Group)
- Having any neurological, psychiatric and psychological diseases that may affect cognitive status
- Taking antipsychiatric medication
- The presence of any visual-auditory intellectual disability
- Having undergone bariatric surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description MetS Group assessment of cognitive performance it consists of volunteer participants diagnosed with MetS between the ages of 18 and 50. All assessments will be applied to the participants by two different researchers at the same time. Control Group assessment of cognitive performance it will consist of healthy individuals aged 18-50 who do not have any health problems and have volunteered to participate in the study who have undergone a health check within the last 6 months.
- Primary Outcome Measures
Name Time Method Evaluation of Metabolic Syndrome-blood pressure once, at baseline "Omron" digital blood pressure monitor will be used to measure systolic and diastolic blood pressure. Participants will be asked to rest for 5 minutes before the measurement.
Evaluation of Metabolic Syndrome-waist circumference once, at baseline Waist Circumference measurement will be recorded with a tape measure in the middle between the last palpable rib and the upper edge of the iliac crest.
Evaluation of Metabolic Syndrome-HDL-C once, at baseline Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Evaluation of Metabolic Syndrome-fasting plasma level once, at baseline Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Metabolic Syndrome Severity Score once, at baseline This scoring creates a z-score by considering factors such as age, race, gender, and metabolic syndrome components values. There is a website that automatically calculates the z-score when these data are entered. (https://metscalc.org/metscalc/)
Evaluation of Metabolic Syndrome-triglyceride once, at baseline Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Monreal Cognitive Assessment once, at baseline This scale consists of parts that evaluate executive functions, attention and concentration, memory, language, abstract thinking, visual-spatial skills, orientation and calculation. The application of MoCA takes about 10 minutes and the total score of the scale is calculated over 30 points. The threshold point value is 21. Scores of 20 or less are considered cognitive dysfunction.
Stroop Test TBAG Form once, at baseline a neuropsychological test that measures focused attention and the speed of information processing
- Secondary Outcome Measures
Name Time Method International Physical Activity Questionnare Short-Form once, at baseline taking into account the last week, the time spent on walking, moderate and vigorous activities is questioned.
Mini Mental State Examination once, at baseline it is a test consisting of 11 questions that evaluate different cognitive parameters, including recording memory, attention and calculation, recall and language, motor function and perception. The maximum score that can be taken from the test is 30 and there is no time limit. In scoring, 24-30 points are normal, 23 points and below indicate mild cognitive impairment.
Visual Reaction Test once, at baseline the participant sees a red circle appearing on a white screen on the computer at variable time intervals and should press the December key of the computer quickly as soon as he sees the circle.
pedometer once, at baseline A valid and reliable method for comparing the participants' weekly step counts and determining their physical activity levels
Trial Locations
- Locations (1)
Bezmialem Vakif University
🇹🇷Istanbul, Turkey