The Effects of Metabolic Syndrome and Its Components on Cognitive Performance and Physical Activity Level in Middle-age Individuals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Syndrome
- Sponsor
- Istanbul University - Cerrahpasa (IUC)
- Enrollment
- 82
- Locations
- 1
- Primary Endpoint
- Evaluation of Metabolic Syndrome-blood pressure
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Metabolic syndrome (MetS) increases the risk of developing diabetes and cardiovascular disease risk factors that are linked with each other, which is a metabolic dysfunction, which contains a combination of multiple.
It is known that METS plays a role in the development of many diseases such as cardiovascular diseases, stroke, cancer, Alzheimer's. Studies have revealed that neuroinflammation, oxidative stress, abnormal lipid metabolism and impaired vascularization, which play a role in the pathogenesis of MetS, affect the structure of the brain and cognition. Atherosclerosis of the carotid artery, increased brain atrophy and white matter damage are potential explanatory mechanisms that lead to an impact on cognitive skills in patients with MetS. In addition, the existence of MetS components such as obesity, diabetes, hypertension alone also negatively affects cognitive functions, and the level of cognitive influence also increases as the number of components an individual has increases.
The literature reports that learning, executive functions, processing speed, attention/working memory and global cognitive functions are affected in individuals with MetS, but no consensus has been reached on this issue. Some studies say that MetS causes a significant decrease in cognitive functions, while some studies indicate that this difference is not significant.
The aim of our study is to proof the relationship between MetS and cognitive functions with metabolic syndrome components.
H1:There is a relationship between the MetS and cognitive functions.
Detailed Description
Voluntary participants who have been diagnosed with MetS and agreed to voluntary health subjects will be included in the study. Signed voluntary consent will be obtained from participants. Participants will be divided into two groups. There will be individuals diagnosed with MetS in the intervention group and healthy individuals who do not have any problems in the control group.
Investigators
Aysenur Erekdag
Investigator
Istanbul University - Cerrahpasa (IUC)
Eligibility Criteria
Inclusion Criteria
- •being between the ages of 18-50
- •Having been educated for at least 5 years and know how to read and write
- •Having been diagnosed with MetS by meeting 3 of the NCEP-ATP III criteria (for participants in the MetS Group)
- •To have a biochemistry test performed within the last 6 months (for the Healthy Group)
- •Not having any MetS components (For the Healthy Group)
Exclusion Criteria
- •Having any neurological, psychiatric and psychological diseases that may affect cognitive status
- •Taking antipsychiatric medication
- •The presence of any visual-auditory intellectual disability
- •Having undergone bariatric surgery
Outcomes
Primary Outcomes
Evaluation of Metabolic Syndrome-blood pressure
Time Frame: once, at baseline
"Omron" digital blood pressure monitor will be used to measure systolic and diastolic blood pressure. Participants will be asked to rest for 5 minutes before the measurement.
Evaluation of Metabolic Syndrome-waist circumference
Time Frame: once, at baseline
Waist Circumference measurement will be recorded with a tape measure in the middle between the last palpable rib and the upper edge of the iliac crest.
Evaluation of Metabolic Syndrome-HDL-C
Time Frame: once, at baseline
Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Evaluation of Metabolic Syndrome-fasting plasma level
Time Frame: once, at baseline
Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Metabolic Syndrome Severity Score
Time Frame: once, at baseline
This scoring creates a z-score by considering factors such as age, race, gender, and metabolic syndrome components values. There is a website that automatically calculates the z-score when these data are entered. (https://metscalc.org/metscalc/)
Evaluation of Metabolic Syndrome-triglyceride
Time Frame: once, at baseline
Triglyceride, HDL-C and fasting plasma levels and biochemistry laboratory findings of individuals will be evaluated. Before the analysis, 8-12 hours of fasting is required so that it does not affect the test results.
Monreal Cognitive Assessment
Time Frame: once, at baseline
This scale consists of parts that evaluate executive functions, attention and concentration, memory, language, abstract thinking, visual-spatial skills, orientation and calculation. The application of MoCA takes about 10 minutes and the total score of the scale is calculated over 30 points. The threshold point value is 21. Scores of 20 or less are considered cognitive dysfunction.
Stroop Test TBAG Form
Time Frame: once, at baseline
a neuropsychological test that measures focused attention and the speed of information processing
Secondary Outcomes
- International Physical Activity Questionnare Short-Form(once, at baseline)
- Mini Mental State Examination(once, at baseline)
- Visual Reaction Test(once, at baseline)
- pedometer(once, at baseline)