Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio in Juvenile Idiopathic Arthritis
Not yet recruiting
- Conditions
- Juvenile Idiopathic Arthritis
- Interventions
- Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)
- Registration Number
- NCT06024486
- Lead Sponsor
- Assiut University
- Brief Summary
The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)
- Detailed Description
The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects
Exclusion Criteria
- Other systemic inflammatory or autoimmune disorders.
- History of corticosteroid medication in the last 6 months.
- Liver diseases.
- Malignancy.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description CONTROL fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR) age and sex matched healthy controls JIA cases fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR) juvenile idiopathic arthritis cases
- Primary Outcome Measures
Name Time Method Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side 3 MONTHS correlation of these ratios with JADAS27
The CRP to albumin ratio 3 MONTHS measurement of serum CRP and albumin
The fibrinogen to albumin ratio 3 months measurement of serum fibrinogen and albumin
- Secondary Outcome Measures
Name Time Method