Periodontal Infection and Systemic Inflammation in Renal Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- Serum Interleukin-6 (IL-6) and C-reactive protein (CRP) levels
研究概览
简要总结
The purpose of this study is to examine the role of gum disease in affecting the long term prognosis of renal patients. This disease if untreated causes inflammatory response throughout the body. If the subject has gum disease, he/she will be randomly assigned to one of the two treatment groups. The study investigates what happens to inflammatory markers in blood and saliva after you are treated for gum disease.
详细描述
The main goal of this project was to explore the contribution of chronic periodontitis to systemic inflammation in Chronic Kidney Disease (CKD). To achieve this goal, the project had two specific objectives:
- a) To compare the prevalence of periodontal infection between CKD and non-CKD populations and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients.
- a) To assess the levels of systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD and b) to compare the serum IL-6 and CRP levels in response to periodontal intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •dental subjects with periodontitis,
- •at least 10 teeth
- •no periodontal (gum) treatment for the last year,
- •no antibiotic for the last 4 months,
- •no vascular access infection.
排除标准
- 未提供
结局指标
主要结局
Serum Interleukin-6 (IL-6) and C-reactive protein (CRP) levels
时间窗: 2 months
IL-6 and CRP are markers of systemic inflammation and may improve at the end of gum treatment.
次要结局
- Changes in periodontal (gum) clinical presentation and status(2 months)
研究者
Efthimia Ioannidou
Associate Professor
UConn Health