Feasibility Study of Biomarker-driven Therapy Based on a Comprehensive Molecular Analysis of Tumor Tissue and Blood Collections in Melanoma
Overview
- Phase
- Not Applicable
- Intervention
- Molecular guided therapy
- Conditions
- Melanoma
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 100
- Primary Endpoint
- Feasibility (number of patients receiving the recommended therapy)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Patients included will undergo biopsy and the molecular analysis will be discussed at the institutional molecular tumor board. The recommandation of the molecular tumor board will be provided to the physician in charge of the patient for final treatment desicion.
The main endpoints are the number of patients with actionable molecular alterations, the number of patients with a treatment recommendation, the number of patients receiving the recommended therapy, overall survival of the patients treated according to recommendations or not. For patients treated according to the recommendations: Response rate and progression free survival at 6 months according to RECIST criteria.
Detailed Description
Eligible patients have to have a histologically proven metastatic melanoma failing standard treatments. Other inclusion criteria included age ≥ 18 years; Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2; life expectancy ≥ 24weeks; adequate renal, liver, and bone marrow functions. Previous therapy with intravenous chemotherapy, immunotherapy or major surgery at least 4 weeks before inclusion was allowed. Patients were excluded if they had a history of cardiac disease or metastatic brain or meningeal tumors. The study is approved by the institutional research ethics board. Molecular analysis is performed at the Max Planck Institute for Molecular Genetics Berlin and a comprehensive report is made available with 4-8 weeks. The molecular tumor board interprets the data and transforms them into treatment recommendations by identifying and prioritizing predictive biomarkers. The recommendations rely on the definition of evidence levels attributed to every single aberration and the interdisciplinary discussion of the aberrations with regard to patient situation, availability of drugs, and clinical trials. The recommendations are transmitted to the physician in charge of the patient for the final decision to treat or not the patient accordingly. The main endpoints are the number of patients with actionable molecular alterations, the number of patients with a treatment recommendation, the number of patients receiving the recommended therapy, overall survival of patients treated according to recommendations or not. For patients treated according to the recommendations: Response rate and progression free survival at 6 months according to RECIST criteria.
Investigators
Ulrich Keilholz
Director Charité Comprehensive Cancer Center
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •histologically proven metastatic melanoma failing standard treatments
- •age ≥ 18 years
- •Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
- •life expectancy ≥ 24 weeks
- •adequate renal, liver, and bone marrow functions
Exclusion Criteria
- •history of cardiac disease or metastatic brain or meningeal tumors
Arms & Interventions
Molecular guided therapy
Intervention: Molecular guided therapy
Outcomes
Primary Outcomes
Feasibility (number of patients receiving the recommended therapy)
Time Frame: Through study completion over 5 years
number of patients receiving the recommended therapy
Feasibility (actionable molecular alterations)
Time Frame: Through study completion over 5 years
number of patients with actionable molecular alterations
Feasibility (number of patients with a treatment recommendation)
Time Frame: Through study completion over 5 years
number of patients with a treatment recommendation
Secondary Outcomes
- Overall survival(5 years)
- Response rate(1 year)
- Progression free survival at 6 months according to RECIST criteria(up to 6 months)