Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- long-interval intracortical inhibition (LICI) level
研究概览
简要总结
Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with hand dystonia : writers cramp
- •Subject affiliated to social security regimen.
- •For healthy volunteers :
- •Healthy volunteer without neurological disorders based on sensorimotor examination.
- •Subject affiliated to social security regimen.
排除标准
- •Subject unable to receive informed consent (dementia).
- •Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).
- •Patient using a psychotrope treatment.
- •Patient under guardianship or curatorship.
- •Pregnant or nursing women.
- •Patient with a cardiac stimulator.
- •For healthy volunteers only :
- •Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)
结局指标
主要结局
long-interval intracortical inhibition (LICI) level
时间窗: Baseline
Amount of inhibition at interstimulus intervals of between 50 to 300ms
次要结局
未报告次要终点