Improved diagnosis for patients with immune-mediated neuropathies

Completed

• Conditions: neuromuscular disorders; 10012303

• Registration Number: NL-OMON44505
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

* Signs and symptoms consistent with Multifocal Motor Neuropathy, Chronic inflammatory demyelinating polyneuropathy or Focal/monomelic Spinal Muscular Atrophy;* Adult (*18 years )
* Fulfilling the EFNS/PNS criteria

Exclusion Criteria

* Subject is unwilling or unable to participate in this study and to give informed consent.
* Legally incompetent adult
* Use of drugs which are known to cause motor neuropathy
* Other diseases known to cause neuropathy or to reduce mobility
* Diseases known to lead to severe handicap or death at short notice
* Subject has a prosthesis which is not verifiable MR-compatible by registration number.
* Contraindications to undergo a MRI scan (I.e. pregnancy, claustrophobia, metal corpora aliena or metal implants such as pacemakers).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlation between MRI, US, NCS, muscle strength, disability scale.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. NCS outcome (EFNS/PNS guideline)<br /><br>a. Temporal dispersion, Conduction velocity, conduction block<br /><br>2. US<br /><br>a. Cross sectional area<br /><br>b. Vascularization<br /><br>c. Echo intensity<br /><br>3. MRI<br /><br>a. Diameters<br /><br>b. Scoring of hyperintensities and swelling<br /><br>c. DTI parameters and architecture of affected nerves and muscles<br /><br>4. Muscle strength * hand-held dynamometry and MRC scores<br /><br>5. Overall Neuropathy Limitations Scale (ONLS)<br /><br>6. INCAT sensory Scale (ISS) </p><br>