Therapeutic Conflicts and Multimorbidity
- Conditions
- Gastrointestinal HemorrhageMultimorbidityDiabetes Complications
- Interventions
- Other: drug-drug or drug-disease interaction
- Registration Number
- NCT02928939
- Lead Sponsor
- University of Zurich
- Brief Summary
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.
- Detailed Description
The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1101
- Inpatients at the University Hospital Zurich, USZ
- Male and female patients, aged 18 years or older
- Fulfilling the criteria for Use Case A or B (i.e. patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs, Use Case A or patients with diabetes mellitus and/or systemic corticosteroids, Use Case B)
- If potential participants have a statement in the electronic medical record or elsewhere to refuse study participation, this represents exclusion criteria.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Multimorbid patients drug-drug or drug-disease interaction -
- Primary Outcome Measures
Name Time Method Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs 5 years Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding?
Patients with diabetes mellitus and systemic corticosteroids 5 years Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus?
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Zurich
🇨ðŸ‡Zurich, Switzerland