Therapeutic Conflicts in Hospitalized Patients: Retrospective Analyses of Patients With GI Bleeding or Exacerbated Diabetes and Impact of Multimorbidity.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,101
- 试验地点
- 1
- 主要终点
- Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs
研究概览
简要总结
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.
详细描述
The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inpatients at the University Hospital Zurich, USZ
- •Male and female patients, aged 18 years or older
- •Fulfilling the criteria for Use Case A or B (i.e. patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs, Use Case A or patients with diabetes mellitus and/or systemic corticosteroids, Use Case B)
排除标准
- •If potential participants have a statement in the electronic medical record or elsewhere to refuse study participation, this represents exclusion criteria.
结局指标
主要结局
Patients with gastrointestinal bleeding and anticoagulants or antiplatelet drugs
时间窗: 5 years
Do anticoagulants or antiplatelet drugs increase the risk of repeated bleeding in patients with gastrointestinal bleeding?
Patients with diabetes mellitus and systemic corticosteroids
时间窗: 5 years
Do systemic corticosteroids increase the risk of exacerbation in patients with diabetes mellitus?
次要结局
未报告次要终点