NCT01595815已完成不适用
Successful Pregnancy and Delivery After AOA in Couples With Repeated Complete Fertilization Failure or Low Fertilization Rates
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Fertilization rate
研究概览
简要总结
Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Fertilization rate was less than 30% after conventional ICSI.
- •Fertilization rate was less than 50% after ICSI with calcium ionophore.
- •Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles
排除标准
- •Fertilization rate was more than 30% after conventional ICSI
- •Fertilization rate was more than 50% after ICSI with calcium ionophore.
- •Successful pregnancy and delivery after ICSI in previous cycles
研究组 & 干预措施
Conventional ICSI
Active Comparator
The couple showed complete fertilization failure after ICSI.
干预措施: Calcium ionophore (Other)
Conventional ICSI
Active Comparator
The couple showed complete fertilization failure after ICSI.
干预措施: Strontium chloride (SrCl2) (Other)
Convention ICSI
Active Comparator
The couple showed a low fertilization rates after ICSI.
干预措施: Calcium ionophore (Other)
Convention ICSI
Active Comparator
The couple showed a low fertilization rates after ICSI.
干预措施: Strontium chloride (SrCl2) (Other)
结局指标
主要结局
Fertilization rate
时间窗: 18 hours
次要结局
- Embryo quality(3 Days)
- Pregnancy and Implantation rates(2 months)
- Assessment of Infant health care(birth and at 3, 6, 12, 24, 36, 60, and 72 months)
研究者
Jun-Woo Kim, Principal Investigator
Maria Fertility Hospital
Maria Fertility Hospital
研究点 (1)
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