A Prospective Cohort Study on Familial Hypercholesterolemia in Health Examination Population
试验速览
- 阶段
- 不适用
- 入组人数
- 318
- 主要终点
- Number of participants with atherosclerotic cardiovascular disease (ASCVD) events
研究概览
简要总结
To determine the prevalence and the prognosis in a corhort of patients with familial hypercholesterolemia (FH).
详细描述
This study aims to achieve the following goals through prospective cohort study and statistical analysis: (1) to determine the prevalence of familial hypercholesterolemia (FH) in healthy people with hypercholesterolemia.（2) Compared with non FH population, the relative risk of atherosclerotic cardiovascular disease (ASCVD) in FH patients in China was calculated, and the risk prediction model of ASCVD in FH patients was constructed by using biochemical results, imaging data, biomarkers and other indicators.（3) To evaluate the benefits of different lipid-lowering strategies for FH patients in China.（4) To analyze the gene carriers of FH patients in China.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with definite diagnosis of hyperlipidemia.
排除标准
- •Do not agree to participate in this study.
- •secondary hypercholesterolemia.
- •Phytosteronemia.
结局指标
主要结局
Number of participants with atherosclerotic cardiovascular disease (ASCVD) events
时间窗: 2 years from enrollmet
1) Fatal or non-fatal myocardial infarction; 2) Fatal or non-fatal ischemic stroke; 3) Coronary artery revascularization; 4) Peripheral artery revascularization; 5) Cardiogenic death
次要结局
未报告次要终点