A Prospective Cohort Study on Familial Hypercholesterolemia in Health Examination Population
- Conditions
- Familial Hypercholesterolemia
- Interventions
- Other: familial hypercholesterolemia
- Registration Number
- NCT04958629
- Lead Sponsor
- Peking University Third Hospital
- Brief Summary
To determine the prevalence and the prognosis in a corhort of patients with familial hypercholesterolemia (FH).
- Detailed Description
This study aims to achieve the following goals through prospective cohort study and statistical analysis: (1) to determine the prevalence of familial hypercholesterolemia (FH) in healthy people with hypercholesterolemia.（2) Compared with non FH population, the relative risk of atherosclerotic cardiovascular disease (ASCVD) in FH patients in China was calculated, and the risk prediction model of ASCVD in FH patients was constructed by using biochemical results, imaging data, biomarkers and other indicators.（3) To evaluate the benefits of different lipid-lowering strategies for FH patients in China.（4) To analyze the gene carriers of FH patients in China.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 318
- Patients with definite diagnosis of hyperlipidemia.
- Age < 18.
- Do not agree to participate in this study.
- secondary hypercholesterolemia.
- Phytosteronemia.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description FH Group familial hypercholesterolemia -
- Primary Outcome Measures
Name Time Method Number of participants with atherosclerotic cardiovascular disease (ASCVD) events 2 years from enrollmet 1) Fatal or non-fatal myocardial infarction; 2) Fatal or non-fatal ischemic stroke; 3) Coronary artery revascularization; 4) Peripheral artery revascularization; 5) Cardiogenic death
- Secondary Outcome Measures
Name Time Method