Efficacy of individualized homoeopathic intervention versus specific homoeopathic intervention using Guaiacum officinale in centesimal scale in reducing rheumatoid factor levels in patients of rheumatoid arthritis: A single-blind randomized controlled trial.

This study is a single-blind randomized controlled trial comparing the efficacy of individualized homoeopathic treatment versus specific homoeopathic intervention with Guaiacum officinale (centesimal scale) in patients with Rheumatoid Arthritis (RA). RA is a chronic autoimmune disease affecting 0.5–1% of the population, more common in women, and often associated with elevated Rheumatoid Factor (RF) levels, which predict severe disease. A total of 60 patients (30 in each group) will be enrolled and treated for 12 weeks. The primary outcome is reduction in RF levels, while secondary outcomes include improvement in disease activity using DAS28 score and clinical symptom relief. Patients in the experimental arm will receive individualized remedies based on totality of symptoms, while the comparator arm will receive Guaiacum officinale. Statistical analysis will assess within- and between-group differences. The trial seeks to establish whether individualized homeopathy offers superior benefits over a fixed specific remedy in RA management