Study of the effects of cytotoxic chemotherapy on oral microcirculation in patients with acute myeloid leukemia (AML)

• Conditions: bloed doorstroming in de microvaten; acute myeloid leukemia; leukemia

• Registration Number: NL-OMON30919
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

1. * Patients receiving chemotherapeutic treatment in the Department of
Clinical Hematology in the Academic Medical Center (AMC)
2. * Patients with acute myeloid leukemia (AML)
3. * Informed consent from each participating patient
4. * Patients older than 18 years

Exclusion Criteria

1. * Severe cardiac and/or pulmonary pathologies
2. * Severe renal function disorders
3. * Hypertension
4. * Patients using anticoagulants or corticosteroids (local or systemic)
5. * Patients with other cancers other than acute myeloid leukemia (AML)
6. * Patients that did not sign an informed consent
7. * Patients younger than 18 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Noninvasive measurements:<br /><br>Sidestream Dark-Field (SDF) Imaging * microcirculation quantification<br /><br><br /><br>Invasive measurements:<br /><br>Blood sample * VEGF, bFGF, and MMPs </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t.</p><br>