Study to compare the effects of cooled dialysis fluid with a normal temperature of dialysis fluid on the pumping function of the heart

Not Applicable

Completed

• Conditions: Chronic kidney disease; Urological and Genital Diseases

• Registration Number: ISRCTN00206012
• Lead Sponsor: Derby Hospitals NHS Foundation Trust (UK)

Brief Summary

1. 2012 study protocol in http://www.ncbi.nlm.nih.gov/pubmed/22720738 2. 2015 results in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527015/

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-10-15
• Study Completion: 2012-12-17
• Last Update Posted: 19 November 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

1. Male and female, age >=16 years old
2. Patients having haemodialysis treatment at least 3 times per week
3. Willing and able to provide consent

Exclusion Criteria

Current exclusion criteria as of 26/04/2012
1. Exposure to haemodialysis >180 days
2. Contraindications for using magnetic resonance imaging (MRI) (e.g. patients with pacemakers and metal implants)
3. Inability to tolerate MRI due to claustrophobia
4. New York Heart Association grade IV heart failure
5. Mental incapacity to consent
6. Pregnancy or lactating patients

Previous exclusion criteria as of 02/02/2012
1. Exposure to haemodialysis >180 days
2. Contraindications for using magnetic resonance imaging (MRI) (e.g. patients with pacemakers and metal implants)
3. Inability to tolerate MRI due to claustrophobia
4. New York Heart Association grade IV heart failure
5. Mental incapacity to consent

Previous exclusion criteria as of 26/04/2011:
1. Exposure to haemodialysis >180 days
2. Contraindications for using magnetic resonance imaging (MRI) (e.g. patients with pacemakers and metal implants)
3. Inability to tolerate MRI due to claustrophobia
4. New York Heart Association grade IV heart failure
5. Cardiac transplant recipients
6. Mental incapacity to consent

Previous exclusion criteria:
1. Exposure to haemodialysis for >90 days
(criteria 2 - 6 remained unchanged)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Resting left ventricular ejection fraction on cardiac magnetic resonance imaging at 12 months.