Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease

• Conditions: Periodontitis, Rheumatoid Arthritis, Autoimmunity,

• Registration Number: NCT02577679
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.

Detailed Description

In patients with RA, the anti-CCP antibody titer seems positively correlated to their periodontal destruction and disease activity in comparison with healthy subjects.

Study Timeline

• Study Start: 2015-06
• Primary Completion: 2015-09
• Study First Submitted: 2015-09-23
• Status Verified: 2015-10
• Study First Submitted QC: 2015-10-14
• Last Update Submitted: 2015-10-14
• Study First Posted: 2015-10-16
• Last Update Posted: 2015-10-16
• Study Completion: 2015-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Not specified
• Target Recruitment: 47

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periodontal pocket depth and clinical attachment level	Baseline	Lower then 4 millimeter: normal Higher then 4 millimeter: diseased/previously diseased
Serum level of anti-cyclic citrullinated peptide/protein antibody	Base line	Lower then 7 Unit/milliliter: negative 7-10 Unit/milliliter: weak positive Higher then 10 Unit/milliliter: positive

Secondary Outcome Measures

Name	Time	Method
Serum level of tumor necrotic factor alpha	Baseline	Recorded in picogram per milliliter
Serum level of interleukin 6	Baseline	Recorded in picogram per milliliter
Serum level of interleukin 17	Baseline	Recorded in picogram per milliliter
Serum level of anti-mutated citrullinated vimentin	Baseline	Recorded in Unit per milliliter

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan