Study of pediatric traumatic brain injuries to establish the appropriate treatment strategies
Not Applicable
- Conditions
- Health Condition 1: S061- Traumatic cerebral edema
- Registration Number
- CTRI/2021/02/031122
- Lead Sponsor
- il Applied for
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Pediatric patients admitted to Neurosurgery ICU and planned for initial conservative management at admission.
GCS <=8 after resuscitation.
Patients presenting within 24 hours of injury
Age 0-18 years
Exclusion Criteria
Patients with polytrauma (Blunt trauma chest, blunt trauma abdomen, long bone fracture or spine injury)
Patients with shock, sepsis, chronic kidney disease, steroid, antiinflammatory drugs or diabetes mellitus
History of encephalitis, CNS vasculitis, meningitis, brain abscess, brain tumor or cranial surgery
Past history of head injury
Patient requiring primary surgery for post-traumatic intracranial hematomas at admission
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. â?¢Comparing effectiveness of Hypertonic Saline and Mannitol will give us the level 1 evidence of superiority between the two to be used after TBI in pediatric population <br/ ><br>2. â?¢After understanding the pathophysiology of cerebral edema with the help of the biomarkers and genetic polymorphism, development of anti-edema measures can be done. <br/ ><br>Timepoint: 2Years
- Secondary Outcome Measures
Name Time Method After the development of anti-edema measures, patients can get early treatment and can be prevented from getting worsened.Timepoint: 2 Years