THE KIMONO-study - on the development of renal injury in children with a solitary functioning kidney.

Completed

• Conditions: Genetica; single kidney; Solitary functioning kidney; 10038360; 10018188

• Registration Number: NL-OMON37570
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Age <18 yrs
Solitary functioning kidney (from congenital or acquired origin, defined as <10% activity on DMSA-scan)

Exclusion Criteria

- treatment for malignant disease during study protocol
- absent informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>KIMONO PRO: Prevalence of renal injury (defined as hypertension, proteinuria<br /><br>and/or a decrease in glomerular filtration rate) in children with an SFK.<br /><br>KIMONO GENE: Identification of new genetic mutations prevalent in children with<br /><br>an SFK.<br /><br>KIMONO BEGIN: National incidence of SFK.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>KIMONO PRO: Devolpment of *early* markers for renal injury.<br /><br>KIMONO GENE: Prevalence of genetic mutations.<br /><br>KIMONO BEGIN: Follow-up of a cohort of children with an (antenatally diagnosed)<br /><br>SFK.</p><br>