Cardiac Arrest Incidence and Outcome Among Patients With COVID-19 in French ICUs
- Conditions
- Sars-CoV2Covid-19
- Interventions
- Other: Modified Rankin scoreOther: Cardiopulmonary resuscitation
- Registration Number
- NCT04373759
- Lead Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
- Brief Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic. Among COVID-19 complications, in-hospital cardiac arrest (IHCA) was reported with a very poor outcome in a retrospective single-center study (0,7% of 30 days survival with good neurological outcome among IHCA patients with a resuscitation attempt), related to its natural course and management. The incidence of unexpected in-ICU cardiac arrest (ICUCA) due to COVID-19 is still unknown. Additionally, outcome of COVID-19 patients admitted in ICU for an out-of-hospital cardiac arrest (OHCA) is also undescribed.
The objective this study is :
* to report the incidence of ICUCA among patients hospitalized in French ICU for COVID-19.
* to report morbidity and mortality among COVID-19 patients admitted alive in ICU for an OHCA or an IHCA.
The secondary objective is to assess outcome and identify risk factors of ICUCA occurrence among patients admitted for COVID-19.
- Detailed Description
Retrospective and prospective multicentric observational registry in French intensive care units (ICU) including all consecutive adult patients admitted in ICU with a documented SARS-CoV-2 disease :
* For an out-of-hospital or an in-hospital cardiac arrest (OHCA and IHCA respectively)
* Or presenting an unexpected in-ICU cardiac arrest (ICUCA) Patients characteristics, cardiac arrest history and patients outcome will be recorded according to Utstein recommendations.
Patients presenting an expected cardiac arrest in ICU related to withdrawal of life sustaining therapies (WLST) will be excluded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 186
- Patients admitted in intensive care unit with a documented SARS-CoV-2 disease
- For an out-of-hospital or an in-hospital cardiac arrest
- Or an in-hospital cardiac arrest
- Or presenting an unexpected in-intensive care unit cardiac arrest
- Age under 18 y.o
- Expected in-intensive care unit cardiac arrest related to withdrawal of life sustaining therapies.
- Withdrawal of patient or next-of-kin informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description In-hospital cardiac arrest patients Modified Rankin score IHCA Patients admitted in intensive care unit for an in-hospital cardiac arrest with a confirmed Covid-19 Unexpected in-intensive care unit cardiac arrest patients Modified Rankin score ICUCA Patients admitted in intensive care unit for a confirmed COVID-19 and presenting an unexpected in-intensive care unit cardiac arrest Unexpected in-intensive care unit cardiac arrest patients Cardiopulmonary resuscitation ICUCA Patients admitted in intensive care unit for a confirmed COVID-19 and presenting an unexpected in-intensive care unit cardiac arrest Out-of-hospital cardiac arrest Modified Rankin score OHCA Patients admitted in intensive care unit for an out-hospital cardiac arrest with a confirmed Covid-19
- Primary Outcome Measures
Name Time Method Incidence of unexpected cardiac arrest 7 months Percentage of unexpected in-intensive care unit cardiac arrest among COVID-19 patients admitted to intensive care unit
- Secondary Outcome Measures
Name Time Method Charlson score 7 months Diabetes, hypertension, smoking, dyslipidemia, coronary artery disease, chronic respiratory insufficiency, chronic heart failure, chronic renal insufficiency, chronic hepatic insufficiency, chronic neurological disease, cancer, malignant hemopathy. Charlson score's minimum and maximum values are 0 and 40 respectively, the lowest score corresponds to a better outcome.
Etiology retained to explain cardiac arrest occurrence 7 months Cardiac origin; Respiratory origin; Metabolic origin; unknown origin
Modified Rankin score (mRS) at ICU discharge, at hospital discharge and at 3 months 3 months 0 - no symptoms at all
1. - no significant disability despite symptoms; able to carry out all usual duties and activities
2. - Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance
3. - Moderate disability; requiring some help, but able to walk without assistance
4. - Moderately severe disability; unable to walk and attend to bodily needs without assistance
5. - Severe disability; bedridden, incontinent and requiring constant nursing care and attention
6. - DeadOrgan failure score at ICU admission and/or before unexpected in-ICU cardiac arrest 7 months Respiratory failure, neurological impairment, circulatory failure, hepatic failure, haematological failure, renal failure. Sofa score's minimum and maximum values are 0 and 24, the lowest score corresponds to a better outcome
Trial Locations
- Locations (36)
CH Etampes
🇫🇷Étampes, Essonne, France
CHU Antoine Béclère AP-HP
🇫🇷Clamart, Haut-de-Seine, France
CHU Pitié Salpétrière
🇫🇷Paris, Ile-de-France, France
CHU Kremlin Bicêtre
🇫🇷Le Kremlin-Bicêtre, Val-de-Marne, France
CHU Dijon
🇫🇷Dijon, Côte-d'Or, France
CH Brive
🇫🇷Brive-la-Gaillarde, Corrèze, France
CHU Saint Louis AP-HP
🇫🇷Paris, Ile-de-France, France
CHU Lariboisière AP-HP
🇫🇷Paris, Ile-de-France, France
CH Louis Mourier AP-HP
🇫🇷Colombes, Hauts-de-Seine, France
CHU St Antoine
🇫🇷Paris, Ile-de-France, France
Groupe Hospitalier Saint Joseph
🇫🇷Paris, Ile-de-France, France
CHU Necker Enfants Malades
🇫🇷Paris, Ile-de-France, France
CHU Felix Guyon
🇫🇷Saint-Denis, La Reunion, France
CH Cahors
🇫🇷Cahors, Lot, France
CHRU Roger Salengro
🇫🇷Lille, Nord, France
Grand Hôpital de l'Est Francilien
🇫🇷Jossigny, Seine-et-Marne, France
CHU Rouen
🇫🇷Rouen, Seine-Maritime, France
CHU Amiens Picardie
🇫🇷Amiens, Somme, France
Hôpital Nord Franche Comté
🇫🇷Trévenans, Territoire De Belfort, France
CH Versailles
🇫🇷Le Chesnay, Yvelines, France
CHU Martinique - Fort de France
🇲🇶Fort-de-France, Martinique
CHR Orléans
🇫🇷Orléans, Loiret, France
CHU Henri Mondor AP-HP
🇫🇷Créteil, Val-de-Marne, France
CH Argenteuil
🇫🇷Argenteuil, Val-d'Oise, France
CHI Frejus St Raphael
🇫🇷Fréjus, Var, France
CH Angoulème
🇫🇷Angoulême, Charente, France
CHU Caen
🇫🇷Caen, Calvados, France
CH Bethune
🇫🇷Beuvry, Pas-de-Calais, France
CH de la Dracénie
🇫🇷Draguignan, Var, France
CHU Ambroise Paré AP-HP
🇫🇷Boulogne-Billancourt, Hauts-de-Seine, France
Hôpital Privé St Martin
🇫🇷Caen, Calvados, France
CHU Montpellier
🇫🇷Montpellier, Hérault, France
CH Lens
🇫🇷Lens, Pas-de-Calais, France
CHU Meaux
🇫🇷Meaux, Seine-et-Marne, France
Groupe Hospitalier Sud Ile de France
🇫🇷Melun, Seine-et-Marne, France
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
🇫🇷Toulon, Var, France