Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT

Not Applicable

Completed

• Conditions: Pleural Effusion; Electric Impedance Tomography; Drainage
• Interventions: Device: Electrical Impedance Tomography record

• Registration Number: NCT03231072
• Lead Sponsor: Czech Technical University in Prague

Brief Summary

Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.

Detailed Description

Critically ill patients treated in intensive care units have a disorder of distribution and volume of body fluids due to principal illness and some therapeutic interventions. One of its manifestations is pleural effusion (PE) formation.

Patients on mechanical ventilation indicated by treating physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured. The purpose of the study is to better understand impact of PE evacuation on aeration and ventilation of the lungs.

Study Timeline

• Study Start: 2017-01-31
• Study First Submitted: 2017-07-18
• Study First Submitted QC: 2017-07-25
• Study First Posted: 2017-07-27
• Primary Completion: 2018-03-30
• Study Completion: 2022-03-30
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-20
• Last Update Posted: 2022-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it

Exclusion Criteria

• impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached
• standard EIT exclusion criteria according to the device manufacturer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Electrical Impedance Tomography record	Electrical Impedance Tomography record	Electrical Impedance Tomography monitoring of the pleural effusion evacuation.

Primary Outcome Measures

Name	Time	Method
Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients	4 hours	Comparison of EIT results with end-expiratory lung volume measurement during drainage of pleural effusion

Secondary Outcome Measures

Name	Time	Method
Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients	4 hours	Change of distribution of ventilation over EIT regions of interest (ROIs)

Trial Locations

Locations (1)

The Military University Hospital; 🇨🇿 Prague, Czechia