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Clinical Trials/NCT03140046
NCT03140046CompletedNot Applicable

Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea

Assiut University1 site in 1 country20 target enrollmentStarted: March 1, 2017Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
20
Locations
1
Primary Endpoint
Visual Acuity

Study Overview

Brief Summary

Irregular astigmatism is one of the most serious and frequent complications of corneal refractive surgery and one of the worst sequelae of other forms of corneal surgery . It is also considered as one of common, serious complications of corneal injuries .

Spectacle correction is usually not useful in the correction of corneal irregular astigmatism. Contact lenses represent a good alternative, but their adaptation and stability are limited by the irregular corneal surface and patient discomfort.

In recent years, advancements in laser technology have offered better tools for dealing with irregular astigmatism with finding new surgical methods to improve corneal regularity for the correction of irregular astigmatism.

Topography-linked excimer laser is a potentially effective technique in the treatment of irregular astigmatism after keratoplasty . In fact, customized ablation was shown to be an effective means of treatment of irregular astigmatism due to different etiologies Such as corneal Injuries , scar , or postoperative.

Some of the theoretical advantages of topography-driven photorefractive keratectomy (PRK) are a better astigmatic correction, the possibility of correcting irregular astigmatism, and a smaller ablation volume compared with standard treatments, resulting in better visual performance.

Aim of the work To evaluate the efficacy, safety, and predictability of topography-guided photorefractive keratectomy (PRK) to improve refractive status of patient with irregular Cornea.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Patients with irregular corneal astigmatism caused by:
  • •Non - Central Corneal Scars.
  • •Previous corneal surgery.
  • •With No other abnormalities in the eye.
  • •Patient is willing to enter the study and sign a consent.

Exclusion Criteria

  • •Patients with central corneal scars.
  • •Patients with central haze interfering with visual acuity.
  • •Patients with ectasia at corneal graft margins.
  • •Patients with irregular astigmatism caused by corneal ectasia or keratoconus.
  • •Patients had refractive surgery with ablations leaving a residual corneal thickness less than 250 μm.

Arms & Interventions

Corneal Topography

Experimental

we will do Corneal Topography for every patient before doing photorefractive keratectomy (PRK) and also after it , to measure the change in the quality of vision and measure the change in the quality of vision

Intervention: photorefractive keratectomy (PRK) (Procedure)

Outcomes

Primary Outcomes

Visual Acuity

Time Frame: follow up after 1 day, 1 week, 1 month and 3 months

The measure of the Visual Acuity and Best Corrected Visual acuity Using the Snellen Chart which give use an idea about visual acuity in Metric scale (e.g. 6\\6 , 6\\12)

Secondary Outcomes

  • Refractive State(follow up after 1 day, 1 week, 1 month and 3 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Ahmed Abdelsamee Mohammed

Dr

Assiut University

Study Sites (1)

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