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临床试验/NCT03140046
NCT03140046已完成不适用

Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea

Assiut University2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2017年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
试验地点
2
主要终点
Visual Acuity

研究概览

简要总结

Irregular astigmatism is one of the most serious and frequent complications of corneal refractive surgery and one of the worst sequelae of other forms of corneal surgery . It is also considered as one of common, serious complications of corneal injuries .

Spectacle correction is usually not useful in the correction of corneal irregular astigmatism. Contact lenses represent a good alternative, but their adaptation and stability are limited by the irregular corneal surface and patient discomfort.

In recent years, advancements in laser technology have offered better tools for dealing with irregular astigmatism with finding new surgical methods to improve corneal regularity for the correction of irregular astigmatism.

Topography-linked excimer laser is a potentially effective technique in the treatment of irregular astigmatism after keratoplasty . In fact, customized ablation was shown to be an effective means of treatment of irregular astigmatism due to different etiologies Such as corneal Injuries , scar , or postoperative.

Some of the theoretical advantages of topography-driven photorefractive keratectomy (PRK) are a better astigmatic correction, the possibility of correcting irregular astigmatism, and a smaller ablation volume compared with standard treatments, resulting in better visual performance.

Aim of the work To evaluate the efficacy, safety, and predictability of topography-guided photorefractive keratectomy (PRK) to improve refractive status of patient with irregular Cornea.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients with irregular corneal astigmatism caused by:
  • Non - Central Corneal Scars.
  • Previous corneal surgery.
  • With No other abnormalities in the eye.
  • Patient is willing to enter the study and sign a consent.

排除标准

  • Patients with central corneal scars.
  • Patients with central haze interfering with visual acuity.
  • Patients with ectasia at corneal graft margins.
  • Patients with irregular astigmatism caused by corneal ectasia or keratoconus.
  • Patients had refractive surgery with ablations leaving a residual corneal thickness less than 250 μm.

结局指标

主要结局

Visual Acuity

时间窗: follow up after 1 day, 1 week, 1 month and 3 months

The measure of the Visual Acuity and Best Corrected Visual acuity Using the Snellen Chart which give use an idea about visual acuity in Metric scale (e.g. 6\\6 , 6\\12)

次要结局

  • Refractive State(follow up after 1 day, 1 week, 1 month and 3 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Abdelsamee Mohammed

Dr

Assiut University

研究点 (2)

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