EUCTR2013-000330-35-AT
Active, not recruiting
Phase 1
Effects of Linagliptin on endothelial function and global arginine bioavailability ratio in coronary artery disease patients with early diabetes - Linagliptin and endothelial function
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Medizinische Universität Graz
- Enrollment
- 50
- Status
- Active, not recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Age 40\-75
- •\- Early diabetes (postchallenge diabetes (2h glucose \>200 mg/dl or type 2 diabetes treated with diet only or on a stable dose of metformin monotherapy)
- •\- Coronary atherosclerosis (diagnosed via coronary angiography or coronary computer tomography)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 35
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range 15
Exclusion Criteria
- •\- Acute coronary syndrome or cerebrovascular event within the previous 4 weeks
- •\-BMI \> 35 kg/m2
- •\- Serum creatinine \> 2\.5 mg/dl
- •\- AST/ALT \> 3x upper limit of normal
- •\- HbA1c \>9\.0% (\>75 mmol/mol)
- •\- Heart failure \> NYHA class II
- •\- Uncontrolled hypertension (blood pressure \> 165 / 100 mmHg)
- •\- Treatment with orally administered steroids
- •\- New onset statin or ACE\-inhibitor within the previous 6 weeks
- •\- Known Malignancy
Outcomes
Primary Outcomes
Not specified
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