Evaluation of Ovarian Reserve in Crohn's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- AMH levels
研究概览
简要总结
Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment. Anti-mullerian hormone (AMH) is a reliable indicator of ovarian reserve in women. The aim of this study was to compare serum AMH levels in women with Crohn's disease and healthy controls. In this study, the investigators aimed to investigate AMH and ovarian capacity in the study group with crohn's disease and in the control group without disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •crohn's disease;
- •reproductive age women
排除标准
- •Over 40 years old,
- •a previous ovarian resection;
- •renal failure (serum creatinine levels N1.2 mg / dL);suspicion of malignancy;
- •the presence of hereditary or acquired hematological disease;
- •pregnancy;
- •current lactation;
- •the presence of a serious comorbid chronic disease;
- •cirrhosis originating from chronic liver disease;
- •abnormal thyroid function tests;
- •a known serious psychological problem;
- •presence of alcoholism and male sex.
结局指标
主要结局
AMH levels
时间窗: 1 MONTH
AMH levels of subjects taken into groups will be evaluated in lg/L
次要结局
- ultrasound findings(1 MONTH)
研究者
Pınar Kadirogulları
pınar kadiroğulları, M.D, Department of Obstetrics and Gynecology
Kanuni Sultan Suleyman Training and Research Hospital