Ovarian Reserve in Crohn's Disease

Completed

• Conditions: Anti-Mullerian Hormone Deficiency; Crohn Disease; Ovary Disease

• Registration Number: NCT03897400
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment. Anti-mullerian hormone (AMH) is a reliable indicator of ovarian reserve in women. The aim of this study was to compare serum AMH levels in women with Crohn's disease and healthy controls. In this study, the investigators aimed to investigate AMH and ovarian capacity in the study group with crohn's disease and in the control group without disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-01
• Study First Submitted: 2019-03-27
• Study First Submitted QC: 2019-03-28
• Study First Posted: 2019-04-01
• Primary Completion: 2019-09-01
• Study Completion: 2019-09-01
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-22
• Last Update Posted: 2019-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• crohn's disease;
• reproductive age women

Exclusion Criteria

• Over 40 years old,
• a previous ovarian resection;
• renal failure (serum creatinine levels N1.2 mg / dL);suspicion of malignancy;
• the presence of hereditary or acquired hematological disease;
• pregnancy;
• current lactation;
• the presence of a serious comorbid chronic disease;
• cirrhosis originating from chronic liver disease;
• abnormal thyroid function tests;
• a known serious psychological problem;
• presence of alcoholism and male sex.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
AMH levels	1 MONTH	AMH levels of subjects taken into groups will be evaluated in lg/L

Secondary Outcome Measures

Name	Time	Method
ultrasound findings	1 MONTH	On the 3rd day of the menstrual cycle, the patients will be given ultrasound and the ovarian volume will be examined. the ovarian volume will be calculated by taking the size of the ovary in three sections.

Trial Locations

Locations (1)

Kanuni Sultan Süleyman Training and Research Hospital; 🇹🇷 Istanbul, Turkey