Handgrip and Respiratory Dysfunction in HD Patients.

Completed

• Conditions: Huntington Disease

• Registration Number: NCT06585332
• Lead Sponsor: General University Hospital, Prague

Brief Summary

Hereditary neurodegenerative diagnosis of Huntington's disease (HD) is associated with a progressive deterioration of the respiratory system function . This fact contributes strongly to the increased risk of aspiration pneumonia as a primary cause of death in people with HD. But regularly objective monitoring of the airway system condition is in common clinical practice almost impossible for high time requirements and the need for specialized expensive devices . This drives the need for a simpler and more cost-effective screening tool. In recent years published studies, working with all ages and genders, show correlation between hand grip strength (HGS) and respiratory parameters. As a second simple screening tool, we chose a short questionnaire called the Index of pulmonary dysfunction.

Detailed Description

Goal: To identify a simple method for screening respiratory muscle and cough weakness in Huntington\'s Disease (HD) patients, suitable for clinical practice.

Hypothesis 1: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with maximal hand grip strength in HD patients.

Hypothesis 2: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with the Index of pulmonary dysfunction in HD patients.

Study Timeline

• Study Start: 2024-04-01
• Study First Submitted: 2024-08-28
• Status Verified: 2024-09
• Study First Submitted QC: 2024-09-02
• Study First Posted: 2024-09-05
• Primary Completion: 2024-10-31
• Study Completion: 2024-10-31
• Last Update Submitted: 2025-03-13
• Last Update Posted: 2025-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Genetic confirmed diagnosis of Huntington's disease

Exclusion Criteria

• diagnosis of other concomitant neurological diseases;
• a history of cardiovascular or lung disease;
• respiratory symptoms such as cough, phlegm, wheezing, or dyspnea at the time of assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maximal Hand grip strength	Up to 35 weeks (once on a single screening visit)	Unit of Measure: kg Assessment followed recommendation of The American Society of Hand Therapists. HSG is measured using DHD-1 digital hand dynamometer (SAEHAN®,Seahan Corporation).
Voluntary peak cough flow	Up to 35 weeks (once on a single screening visit)	Unit of measure: l/min Assessments will be performed in accordance with American Thoracic Society/European Thoracic Society guidelines.
Maximal expiratory pressure, Maximal inspiratory pressure	Up to 35 weeks (once on a single screening visit)	Unite of measure: cmH2O Assessments will be performed in accordance with American Thoracic Society/European Thoracic Society guidelines.

Secondary Outcome Measures

Name	Time	Method
Index of Pulmonary dysfunction	Up to 35 weeks (once on a single screening visit)	Questionnaire of four questions. Scale range: 0-11 points A higher score indicates a worse pulmonary condition.

Trial Locations

Locations (1)

General University Hospital; 🇨🇿 Prague, Czechia