The Use of Chinese Herbal Medicine and Vitamin C by Hospital Care Workers in Hong Kong Mobile Cabin Hospital to Prevent COVID-19 Transmission: A Prospective, Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 入组人数
- 652
- 主要终点
- Proportion of subjects who become SARS-CoV-2 positive
研究概览
简要总结
This is a prospective randomized controlled trial study to explore whether the combination of Chinese herbal medicine and Vitamin C is effective and safe to prevent COVID-19 transmission among health care workers in Hong Kong Mobile Cabin Hospital governed by the Hong Kong Hospital Authority who have been caring for patients with COVID-19. A total of 652 adults will be enrolled. Eligible subjects who provide written informed consent will be assessed for inclusion/exclusion criteria.
All participants are asymptomatic and test negative for SARS-CoV-2 at the study's commencement. Subjects with major medical illness, renal insufficiency and hypersensitivity to Chinese herbal medicine will be excluded. All participants will receive Vitamin C (VC) supplementation and 28 packets of the herbal medicine free of charge and are advised to consume daily for 14 days. After written informed consent, the subjects will be included and randomly allocated to either CHM+VC group or VC treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Health care workers in Hong Kong Mobile Cabin Hospital;
- •Asymptomatic and test negative for SARS-CoV-2;
- •Voluntarily signing a written informed consent form;
排除标准
- •With major medical illness or renal insufficiency;
- •With hypersensitivity to Chinese herbal medicine;
- •Pregnancy or lactation.
研究组 & 干预措施
CHM+Vc
Participants in CHM+VC group are required to consume vitamin C 1000mg/day and 1 sachet (9 g) of granules daily (1 hour after meal by dissolving 1 sachet of 9g granules in 150 ml of hot water and drink it orally) .
干预措施: Chinese herbal medicine (Drug)
Vc
Participants will receive vitamin C 1000mg/day for 14 days
干预措施: Chinese herbal medicine (Drug)
结局指标
主要结局
Proportion of subjects who become SARS-CoV-2 positive
时间窗: 4 weeks
次要结局
- Number of days of confirmed SARS-CoV-2 infection(4 weeks)
- Duration of COVID-19-related symptoms in confirmed SARS-CoV-2 infection cases(4 weeks)
- Safety endpoint(4 weeks)
研究者
ZhaoXiang Bian
Professor
Hong Kong Baptist University