A preliminary, multicenter study on the relationship between cortical damage and blood brain barrier damage in Multiple Sclerosis patients with high cortical disease activity. Correlation between [11C]-PK-11195 or [18F]-NAF PET (Positron Emission Tomography) and high field MRI (Magnetic Resonance Imaging): a synergistic effect by using a double-technique approach. - A preliminary, multicenter study on the relationship between cortical damage and blood brain barrier

AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA VERONA0 个研究点目标入组 18 人开始时间: 2021年6月8日最近更新: 2021年8月17日

适应症

试验速览

暂无简介。

•- Sex: Female and Male
•- Age: = 18 years old
•- Diagnosis of Multiple Sclerosis according to McDonald criteria, 2010 rev.
•- EDSS 0-5.5
•- Cerebral MRI with Gadolinium within two weeks the PET scanning
•- High cortical disease activity (presence of at least 10 cortical lesions and/or epilepsy/seizures not secondary to non-MS pathology) and/or severe mnestic or executive impairment in neuropsychological tests.
•- informed consent
•- for [18F]-NaF-PET study, a sub-group of patients who presented seizures in the past 2 months will be chosen
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 18
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 0

•- Co-occurring of other illness that can alter PET imaging (neoplasms, infectious disease, etc)
•- previous brain surgery
•- pregnancy (for women in reproductive age, a b-HCG test will be performed) or breast feeding
•- allergy or intolerance to one or more of the drugs employed in this study

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