Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- evaluation of the autonomic function in resistant hypertensive patients
Study Overview
Brief Summary
The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.
Detailed Description
All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.
Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
Eligibility Criteria
- Ages
- 30 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •resistant hypertensive patients
Exclusion Criteria
- •White-coat hypertension
- •obstructive sleep apnea
Outcomes
Primary Outcomes
evaluation of the autonomic function in resistant hypertensive patients
Time Frame: 10 months
The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability. In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours
Secondary Outcomes
No secondary outcomes reported
Investigators
Valéria Nasser Figueiredo
PhD
University of Campinas, Brazil