Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 113
- 试验地点
- 1
- 主要终点
- Photoacoustic Imaging
研究概览
简要总结
The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.
详细描述
The objective of this proposal is to adapt photoacoustic tomography (PAT), a novel, nonionizing, noninvasive, laser-based technology, for structural and functional imaging of human peripheral joints affected by inflammatory arthritis.
Combining the advantages of both light and ultrasound scanning, PAT holds promise to present objective optical information in subsurface joint tissues with high sensitivity and high spatial resolution.
This could be of considerable help in the early detection of inflammatory joint diseases. PAT may also prove useful in further understanding the pathophysiology of these disorders and assisting with therapeutic decisions, including assessment of new pharmacological therapies.
In January 2026, the decision was made to reopen recruitment for this study to collect additional data to support future clinical trial work and funding.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women 18 years of age or older can participate in this study.
- •Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study.
- •Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis.
排除标准
- •Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator.
- •Pregnant patients.
- •Patients who is claustrophobic.
- •Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc.
- •Patients with shock hypotension or unstable low blood pressure.
- •Patients with Rhabdomyolysis.
- •Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures).
研究组 & 干预措施
Rheumatoid Arthritis
Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound
干预措施: Laser Based Photoacoustic Tomography, MRI, Ultrasound (Procedure)
Normal controls
Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand
干预措施: laser based photoacoustic tomography, MRI, ultrasound (Procedure)
结局指标
主要结局
Photoacoustic Imaging
时间窗: 10 weeks
To determine if photoacoustic imaging (PAT) can accurately assist in the diagnosis of chronic rheumatoid arthritis, with data collected every 2 weeks for a maximum of 10 weeks.
次要结局
未报告次要终点
研究者
Xueding Wang
Principal Investigator
University of Michigan