EVALUATION OF HIV DISTRIBUTION IN DIFFERENT TISSUES
- Conditions
- Health Condition 1: null- Patients that are diagnosed with HIV with reliable index such as detection of HIV in plasma (viral load in plasma), ELISA or Western blot
- Registration Number
- CTRI/2018/03/012342
- Lead Sponsor
- iProcess Global Research Organization
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria for HIV donors:
1-At least 18 years old
2-Must be able to provide written informed consent or donors that have deceased their family must provide informed consent
3-Donors should be diagnosed with HIV with reliable index such as detection of HIV in plasma (viral load in plasma), ELISA or Western blot data in detection of p24, GP160 and/or GP41 protein and its antibody in plasma.
4-HIV status: both viremic and suppressed aviremic donors (viral load less than 50 copies/ml) treated with ART will be accepted.
Inclusion Criteria for Healthy donors:
1-At least 18 years old
2-Must be able to provide written informed consent or donors that have deceased their family must provide informed consent.
3-Samples should be from healthy tissues (i.e. not cancerous or other condition currently receiving treatment).
Exclusion Criteria for HIV donors:
1-HIV donors who are co-infected with the hepatitis C virus
2-Active cancer
Exclusion Criteria for Healthy donors:
1-Infected with HIV or other infectious disease including hepatitis C virus
2-Active cancer
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determine which organ tissue cells contain HIV markers and the variance in distribution among the different tissues <br/ ><br>Timepoint: 6 months
- Secondary Outcome Measures
Name Time Method â?¢Determine the level of P24, cell associated HIV unspliced or multiple splicing RNA; proviral DNA reservoir size.Timepoint: 6 months