Direct Electrical Stimulation of Central Autonomic Network for Blood Pressure Control: a Mechanism Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 主要终点
- blood pressure
研究概览
简要总结
The primary objective of this research is to study direct electrical stimulation of central autonomic network for blood pressure control.
详细描述
This project aims to include 20 participants, and evaluate the direct electrical stimulation of central autonomic network for blood pressure control through A pilot, prospective clinical trial. It is expected to explore potential blood pressure regulation-related targets in the central autonomic neural network and provide a neuromodulation approach for the treatment of blood pressure disorders, including refractory hypertension and neurogenic orthostatic hypotension.
研究设计
- 研究类型
- 干预性
- 分配方式
- 不适用
- 干预模型
- 单组
- 主要目的
- 治疗
- 盲法
- 开放（无盲法）
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- Aged 18-60 years, with no gender restrictions.
- Free from severe systemic diseases.
- Patients who have undergone stereoelectroencephalography electrode implantation.
- Patients who have been informed of potential risks, consented to participate in this study, and signed the informed consent form.
- Daytime clinic blood pressure fluctuates within the following range: 90 mmHg < systolic blood pressure < 140 mmHg; 60 mmHg < diastolic blood pressure < 90 mmHg.
排除标准
- Patients with scalp electrode hematoma or sub-electrode effusion after intracranial electrode implantation, who are unable to receive electrical stimulation.
- Patients with intracranial structural lesions (e.g., encephalomalacia foci, vascular malformations, space-occupying lesions, etc.).
- Pregnant women.
- Patients who are unable to cooperate due to mental disorders or other causes.
- Patients who have participated in other clinical trials within the past 3 months.
- Patients who apply to withdraw from this clinical trial for any reason.
- Patients with cardiac or pulmonary insufficiency.
- Patients with white coat effect are excluded.
- Patients with low cerebrovascular risk assessed by cranial magnetic resonance imaging (MRI).
研究组 & 干预措施
Direct electrical stimulation
Patients with hypertension and drug-resistant focal epilepsy who underwent intracranial monitoring via stereotactically implanted depth electrodes (SEEG) are assigned to Direct electrical stimulation for 30 sec per mission.
干预措施: direct electrical stimulation (Other)
结局指标
主要结局
blood pressure
时间窗: up to 4 hours
Blood Pressure is defined as the blood pressure measurement obtained 30 minutes after the completion of direct electrical stimulation.
次要结局
未报告次要终点
研究者
标识符
- NCT 编号
- NCT07844239
- 其他研究编号
- 2025-330-002
日期
- 首次提交
- (8天前)
- 首次发布
- (前天)
- 主要完成日期
- (3个月后)
- 研究完成日期
- (3个月后)
- 最近核实
- (10个月前)
- 最近更新
- (前天)
监管与共享
- FDA 监管药物
- 否
- FDA 监管器械
- 否
- 个体参与者数据共享计划
- 否
- 是否有结果
- 否