The study of specific protein markers in pineal parenchymal tumors - Pineal parenchymal tumors

In human tissue, HIOMT was expressed in retinal cells, pineal parenchymal cells, neurons of the Edinger-Westphal nucleus, microglia, macrophages, thyroid follicular epithelium, principal and oxyphil cells of parathyroid gland, adrenal cortical cells, hepatic parenchymal cells, renal tubule epithelial cells, and enteroendocrine cells of stomach and duodenum. HIOMT was expressed in all PPTs studied. The ratio of HIOMT-immunoreactive cells successively decreased in the following tumors: pineocytoma, pineocytomatous area of PPTIDs, PPTID, pineoblastomatous area of PPTIDs, and pineoblastoma. In one of three PNETs and four of eight MBs, a few HIOMT-immunoreactive cells were observed. HIOMT immunohistochemistry is useful in diagnosing PPTs and may be one of the predictive factors affecting the survival of PPTs.